Research workbench
Structure of candida glabrata CSM1:DSN1(14-72) complex
Analyse Structure of candida glabrata CSM1:DSN1(14-72) complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6MJB
- Type
- protein
- Length
- 254 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Monopolin complex subunit CSM1; Kinetochore-associated protein DSN1
- UniProt
- A0A0W0CH22, A0A0W0D923
- Pockets
- 4 · best druggability 0.43
Structure
x-ray diffraction · 3 distinct chains · 38% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Monopolin complex subunit CSM1 | protein | 104 | 40% helix, 38% strand | A0A0W0CH22 |
| B | Monopolin complex subunit CSM1 | protein | 113 | 37% helix, 36% strand | A0A0W0CH22 |
| C | Kinetochore-associated protein DSN1 | protein | 37 | 35% helix, 5% strand | A0A0W0D923 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 100 | 0.43 | 0.78 | 20 | empty |
| 2 | 63 | 0.39 | 0.79 | 11 | empty |
| 3 | 102 | 0.34 | 0.73 | 23 | empty |
| 4 | 80 | 0.31 | 0.73 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1274 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 1203 Ų buried · 25 hydrogen bonds · protein-protein
- B–C · 121 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6MJB · Structure of Candida glabrata Csm1:Dsn1(14-72) complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0W0CH22
- Every structure of UniProt A0A0W0D923
- Elsewhere: RCSB PDB 6MJB · PDBe 6MJB · UniProt A0A0W0CH22 · UniProt A0A0W0D923
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