Research workbench
Structure of connexin-46 intercellular gap junction channel at 3.4 ångström resolution by cryoem
Analyse Structure of connexin-46 intercellular gap junction channel at 3.4 ångström… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6MHQ
- Type
- protein
- Length
- 2,124 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gap junction alpha-3 protein, connexin-46
- UniProt
- Q9TU17
- Pockets
- 20 · best druggability 0.58
Structure
electron microscopy · 1 distinct chain · 70% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L | Gap junction alpha-3 protein, connexin-46 | protein | 177 | 70% helix, 5% strand | Q9TU17 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 75 | 0.58 | 0.88 | 18 | empty |
| 2 | 91 | 0.58 | 0.86 | 19 | empty |
| 3 | 94 | 0.57 | 0.86 | 20 | empty |
| 4 | 86 | 0.57 | 0.86 | 19 | empty |
| 5 | 80 | 0.57 | 0.87 | 17 | empty |
Interfaces
24 interfaces between chains.
- A–F · 1372 Ų buried · 6 hydrogen bonds · protein-protein
- I–J · 1371 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 1370 Ų buried · 6 hydrogen bonds · protein-protein
- G–L · 1370 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 1369 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 36 disulfide (disulfide).
Compared structures
- 6MHQ · Structure of connexin-46 intercellular gap junction channel at 3.4 angstrom resolution by… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9TU17
- Elsewhere: RCSB PDB 6MHQ · PDBe 6MHQ · UniProt Q9TU17
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