Research workbench
Crystal structure of broadly neutralizing antibody AR3C
Analyse Crystal structure of broadly neutralizing antibody AR3C in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6MEF
- Type
- protein
- Length
- 436 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Antibody AR3C heavy chain; Antibody AR3C light chain
- Pockets
- 4 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Antibody AR3C heavy chain | protein | 224 | 5% helix, 50% strand | — |
| L | Antibody AR3C light chain | protein | 212 | 7% helix, 52% strand | — |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 566 | 0.62 | 0.74 | 67 | empty |
| 2 | 201 | 0.47 | 0.75 | 34 | empty |
| 3 | 61 | 0.29 | 0.74 | 14 | empty |
| 4 | 50 | 0.25 | 0.73 | 12 | empty |
Interfaces
1 interface between chains.
- H–L · 1794 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 6MEF · Crystal structure of broadly neutralizing antibody AR3C · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6MEF · PDBe 6MEF
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