Research workbench
Crystal structure of inward rectifier KIR2.2 in a different salt condition
Analyse Crystal structure of inward rectifier KIR2.2 in a different salt condition in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6M85
- Type
- protein
- Length
- 327 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-sensitive inward rectifier potassium channel 12
- UniProt
- F1NHE9
- Ligands
- K
- Pockets
- 2 · best druggability 0.39
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATP-sensitive inward rectifier potassium channel 12 | protein | 327 | 34% helix, 28% strand | F1NHE9 |
Ligands and binding sites
- K · Potassium ion · metal · 6 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 100 | 0.39 | 0.76 | 17 | empty |
| 2 | 68 | 0.29 | 0.73 | 20 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6M85 · Crystal Structure of Inward Rectifier Kir2.2 in a different salt condition · the same entry in another collection · chain A against A, TM-score 1.00
- F1NHE9 · AlphaFold monomer V2.0 prediction for ATP-sensitive inward rectifier potassium channel 12… · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt F1NHE9
- Elsewhere: RCSB PDB 6M85 · PDBe 6M85 · UniProt F1NHE9
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