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The crystal structure of B. subtilis RSBV/RSBW complex in the monoclinic crystal form

Analyse The crystal structure of B. subtilis RSBV/RSBW complex in the monoclinic… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6M36
Type: protein
Length: 1,619 residues
Chains: 16
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Serine-protein kinase rsbw; Anti-sigma-B factor antagonist
EC: 2.7.11.1
UniProt: P17904, P17903
Pockets: 19 · best druggability 0.70

Structure

x-ray diffraction · 10 distinct chains · 43% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, K	Serine-protein kinase rsbw (EC 2.7.11.1)	protein	103	45% helix, 35% strand	P17904
B, J, P	Anti-sigma-B factor antagonist	protein	100	37% helix, 35% strand	P17903
C, M	Serine-protein kinase rsbw (EC 2.7.11.1)	protein	105	47% helix, 32% strand	P17904
D	Anti-sigma-B factor antagonist	protein	99	39% helix, 33% strand	P17903
E	Serine-protein kinase rsbw (EC 2.7.11.1)	protein	100	42% helix, 32% strand	P17904
F	Anti-sigma-B factor antagonist	protein	95	43% helix, 35% strand	P17903
G	Serine-protein kinase rsbw (EC 2.7.11.1)	protein	104	45% helix, 35% strand	P17904
H, L, N	Anti-sigma-B factor antagonist	protein	101	37% helix, 36% strand	P17903
I	Serine-protein kinase rsbw (EC 2.7.11.1)	protein	104	43% helix, 34% strand	P17904
O	Serine-protein kinase rsbw (EC 2.7.11.1)	protein	98	47% helix, 32% strand	P17904

Pockets

19 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	875	0.70	0.76	99	empty
2	707	0.67	0.75	72	empty
3	419	0.61	0.77	54	empty
4	328	0.56	0.75	31	empty
5	238	0.56	0.78	38	empty

Interfaces

35 interfaces between chains.

I–K · 839 Å² buried · 9 hydrogen bonds · protein-protein
A–C · 834 Å² buried · 12 hydrogen bonds · protein-protein
C–D · 797 Å² buried · 15 hydrogen bonds · protein-protein
G–H · 795 Å² buried · 12 hydrogen bonds · protein-protein
I–J · 793 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

6M36 · The crystal structure of B. subtilis RsbV/RsbW complex in the monoclinic crystal form · the same entry in another collection · chain K against K, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P17904
Every structure of UniProt P17903
Elsewhere: RCSB PDB 6M36 · PDBe 6M36 · UniProt P17904 · UniProt P17903

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