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Cryo-EM structure of ATMSL1 wild type

Analyse Cryo-EM structure of ATMSL1 wild type in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6LYP
Type: protein
Length: 2,009 residues
Chains: 7
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mechanosensitive ion channel protein 1, mitochondrial
UniProt: Q8VZL4
Pockets: 20 · best druggability 0.73

Structure

electron microscopy · 1 distinct chain · 44% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G	Mechanosensitive ion channel protein 1, mitochondrial	protein	287	44% helix, 16% strand	Q8VZL4

Pockets

20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	938	0.73	0.77	54	empty
2	526	0.68	0.79	78	empty
3	487	0.67	0.79	78	empty
4	500	0.66	0.77	71	empty
5	300	0.60	0.78	45	empty

Interfaces

7 interfaces between chains.

E–F · 2591 Å² buried · 19 hydrogen bonds · protein-protein
A–G · 2546 Å² buried · 14 hydrogen bonds · protein-protein
C–D · 2545 Å² buried · 13 hydrogen bonds · protein-protein
F–G · 2544 Å² buried · 16 hydrogen bonds · protein-protein
B–C · 2534 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

6LYP · Cryo-EM structure of AtMSL1 wild type · the same entry in another collection · chain G against G, TM-score 1.00
Q8VZL4 · AlphaFold monomer V2.0 prediction for mechanosensitive ion channel protein 1… · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8VZL4
Elsewhere: RCSB PDB 6LYP · PDBe 6LYP · UniProt Q8VZL4

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