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Dimeric isocitrate dehydrogenase from xanthomonas campestris pv. campestris 8004

Analyse Dimeric isocitrate dehydrogenase from xanthomonas campestris pv. campestris 8004 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6LTF
Type: protein
Length: 334 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Isocitrate dehydrogenase
EC: 1.1.1.41
UniProt: A0A2S4JWD6
Ligands: BEZ
Pockets: 4 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Isocitrate dehydrogenase (EC 1.1.1.41)	protein	334	44% helix, 19% strand	A0A2S4JWD6

Ligands and binding sites

BEZ · Benzoic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	146	0.65	0.87	37	empty
2	208	0.50	0.76	33	empty
3	54	0.42	0.82	12	BEZ
4	83	0.34	0.74	19	empty

Compared structures

6LTF · Dimeric isocitrate dehydrogenase from Xanthomonas campestris pv. campestris 8004 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A2S4JWD6
Elsewhere: RCSB PDB 6LTF · PDBe 6LTF · UniProt A0A2S4JWD6

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