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The complex structure of phf core domain peptide of tau and ANTIBODY'S Fab domain.

Analyse The complex structure of phf core domain peptide of tau and ANTIBODY'S Fab… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6LRA
Type: protein
Length: 444 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fab heavy chain; Fab light chain; Vqiink
Pockets: 5 · best druggability 0.55

Structure

x-ray diffraction · 3 distinct chains · 9% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	Fab heavy chain	protein	218	10% helix, 51% strand	—
L	Fab light chain	protein	220	8% helix, 55% strand	—
C	Vqiink	protein	6	0% helix, 0% strand	—

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	340	0.55	0.75	46	empty
2	93	0.37	0.75	19	empty
3	84	0.34	0.74	20	empty
4	79	0.31	0.73	17	empty
5	51	0.31	0.77	10	empty

Interfaces

3 interfaces between chains.

H–L · 1892 Å² buried · 19 hydrogen bonds · protein-protein
L–C · 281 Å² buried · 7 hydrogen bonds · protein-protein
H–C · 257 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

6LRA · The complex structure of PHF core domain peptide of tau and antibody's Fab domain. · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6LRA · PDBe 6LRA

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