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NMR solution structure of VEGF G-quadruplex bound a non-planar cyclometalated-carbene PLATINUM(II) complex

Analyse NMR solution structure of VEGF G-quadruplex bound a non-planar… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6LNZ
Type: DNA
Length: 22 nucleotides
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA (5'- D(*CP*GP*GP*GP*GP*CP*GP*GP*GP*CP*CP*TP*TP*GP*GP*GP*CP*GP*GP*GP*GP*T)- 3')
Ligands: EL9
Pockets: 1 · best druggability 0.34

Structure

solution nmr · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA (5'- D(CPGPGPGPGPCPGPGPGPCPCPTPTPGPGPGPCPGPGPGPGPT)- 3')	dna	22	—	—

Ligands and binding sites

EL9 · cyclometalated-carbene platinum(II) complex · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	70	0.34	0.77	10	empty

Compared structures

6LNZ · NMR solution structure of VEGF G-quadruplex bound a non-planar cyclometalated-carbene… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6LNZ · PDBe 6LNZ

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