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High resolution structure of fanca C-terminal domain (ctd)

Analyse High resolution structure of fanca C-terminal domain (ctd) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6LHS
Type: protein
Length: 1,456 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fanconi anemia complementation group a
UniProt: Q4VT51
Pockets: 20 · best druggability 0.82

Structure

electron microscopy · 2 distinct chains · 47% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Fanconi anemia complementation group a	protein	719	47% helix, 0% strand	Q4VT51
A	Fanconi anemia complementation group a	protein	737	47% helix, 1% strand	Q4VT51

Pockets

20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	856	0.82	0.84	91	empty
2	150	0.78	0.95	31	empty
3	88	0.74	0.96	17	empty
4	70	0.73	0.97	13	empty
5	146	0.68	0.89	27	empty

Interfaces

1 interface between chains.

B–A · 3386 Å² buried · 28 hydrogen bonds · protein-protein

Compared structures

6LHS · High resolution structure of FANCA C-terminal domain (CTD) · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q4VT51
Elsewhere: RCSB PDB 6LHS · PDBe 6LHS · UniProt Q4VT51

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