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Crystal structure of chicken 8MER-BF2*1501

Analyse Crystal structure of chicken 8MER-BF2*1501 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6LHH
Type: protein
Length: 376 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: MHC class I; Beta-2-microglobulin; Arg-arg-arg-glu-gln-thr-asp-tyr
UniProt: Q9GIP6, P21611
Pockets: 3 · best druggability 0.67

Structure

x-ray diffraction · 3 distinct chains · 19% helix, 43% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	MHC class I	protein	270	26% helix, 41% strand	Q9GIP6
B	Beta-2-microglobulin	protein	98	0% helix, 51% strand	P21611
C	Arg-arg-arg-glu-gln-thr-asp-tyr	protein	8	0% helix, 0% strand	—

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	484	0.67	0.78	55	empty
2	110	0.39	0.75	15	empty
3	65	0.32	0.75	22	empty

Interfaces

2 interfaces between chains.

A–B · 1667 Å² buried · 22 hydrogen bonds · protein-protein
A–C · 1003 Å² buried · 18 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

6LHH · Crystal structure of chicken 8mer-BF2*1501 · the same entry in another collection · chain A against A, TM-score 1.00
P21611 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P21611) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9GIP6
Every structure of UniProt P21611
Elsewhere: RCSB PDB 6LHH · PDBe 6LHH · UniProt Q9GIP6 · UniProt P21611

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