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Isoleucyl-tRNA synthetase from candida albicans complexed with a isoleucyl-adenylate

Analyse Isoleucyl-tRNA synthetase from candida albicans complexed with a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6LDK
Type: protein
Length: 813 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Isoleucine--tRNA ligase
EC: 6.1.1.5
UniProt: Q59RI1
Ligands: AMP, ILE
Pockets: 8 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Isoleucine--tRNA ligase (EC 6.1.1.5)	protein	813	44% helix, 19% strand	Q59RI1

Ligands and binding sites

AMP · Adenosine monophosphate · ligand · chains A
ILE · Isoleucine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	688	0.78	0.83	54	AMP, ILE
2	691	0.67	0.76	63	empty
3	188	0.62	0.83	30	empty
4	170	0.56	0.81	19	empty
5	147	0.46	0.77	27	empty

Compared structures

6LDK · Isoleucyl-tRNA synthetase from Candida albicans complexed with a isoleucyl-adenylate · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q59RI1
Elsewhere: RCSB PDB 6LDK · PDBe 6LDK · UniProt Q59RI1

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