Research workbench

Crystal structure of ampc ENT385 free form

Analyse Crystal structure of ampc ENT385 free form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6LC7
Type: protein
Length: 705 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-lactamase
EC: 3.5.2.6
Ligands: SO4
Pockets: 7 · best druggability 0.64

Structure

x-ray diffraction · 2 distinct chains · 39% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Beta-lactamase (EC 3.5.2.6)	protein	358	38% helix, 23% strand	—
B	Beta-lactamase (EC 3.5.2.6)	protein	347	40% helix, 23% strand	—

Ligands and binding sites

SO4 · Sulfate ion · ion · 10 copies · chains A, B
GOL · Glycerol · additive · 7 copies · chains A, B
DIO · 1,4-diethylene dioxide · additive · 2 copies · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	538	0.64	0.76	63	GOL, SO4
2	130	0.44	0.76	31	empty
3	145	0.42	0.74	29	GOL
4	85	0.40	0.78	14	GOL
5	96	0.35	0.74	28	SO4

Interfaces

1 interface between chains.

A–B · 715 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

6LC7 · Crystal structure of AmpC Ent385 free form · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6LC7 · PDBe 6LC7

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.