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The ligand-free structure of human ppargamma lbd

Analyse The ligand-free structure of human ppargamma lbd in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6L8B
Type: protein
Length: 525 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Peroxisome proliferator-activated receptor gamma
UniProt: P37231
Pockets: 9 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 67% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Peroxisome proliferator-activated receptor gamma	protein	264	68% helix, 5% strand	P37231
B	Peroxisome proliferator-activated receptor gamma	protein	261	66% helix, 5% strand	P37231

Pockets

9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	505	0.81	0.88	50	empty
2	329	0.81	0.91	41	empty
3	246	0.59	0.79	27	empty
4	368	0.59	0.76	37	empty
5	129	0.56	0.83	21	empty

Interfaces

1 interface between chains.

A–B · 908 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

6L8B · The ligand-free structure of human PPARgamma LBD · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37231
Elsewhere: RCSB PDB 6L8B · PDBe 6L8B · UniProt P37231

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