Research workbench
Csgfg complex with substrate CSGAN6 peptide in curli biogenesis system
Analyse Csgfg complex with substrate CSGAN6 peptide in curli biogenesis system in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6L7C
- Type
- protein
- Length
- 2,655 residues
- Chains
- 27
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Curli production ASSEMBLY/TRANSPORT protein csgg; Csgf; Major curlin subunit csga
- UniProt
- A0A027ZN26, B2CY45, A0A4S4PI16
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 3 distinct chains · 26% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I | Curli production ASSEMBLY/TRANSPORT protein csgg | protein | 253 | 26% helix, 37% strand | A0A027ZN26 |
| J, K, L, M, N, O, P, Q, R | Csgf | protein | 36 | 33% helix, 6% strand | B2CY45 |
| S, T, U, V, W, X, Y, Z, a | Major curlin subunit csga | protein | 6 | 0% helix, 0% strand | A0A4S4PI16 |
Pockets
20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 764 | 0.86 | 0.90 | 149 | empty |
| 2 | 380 | 0.81 | 0.90 | 76 | empty |
| 3 | 52 | 0.70 | 0.98 | 22 | empty |
| 4 | 50 | 0.69 | 0.98 | 21 | empty |
| 5 | 50 | 0.68 | 0.97 | 19 | empty |
Interfaces
63 interfaces between chains.
- B–C · 3214 Ų buried · 55 hydrogen bonds · protein-protein
- A–B · 3210 Ų buried · 56 hydrogen bonds · protein-protein
- D–E · 3203 Ų buried · 55 hydrogen bonds · protein-protein
- H–I · 3199 Ų buried · 52 hydrogen bonds · protein-protein
- C–D · 3195 Ų buried · 55 hydrogen bonds · protein-protein
Compared structures
- 6L7C · CsgFG complex with substrate CsgAN6 peptide in Curli biogenesis system · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A027ZN26
- Every structure of UniProt B2CY45
- Every structure of UniProt A0A4S4PI16
- Elsewhere: RCSB PDB 6L7C · PDBe 6L7C · UniProt A0A027ZN26 · UniProt B2CY45 · UniProt A0A4S4PI16
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