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HASIC2A co-crystallized with mamb-1

Analyse HASIC2A co-crystallized with mamb-1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6L6P
Type: protein
Length: 1,297 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Acid-sensing ion channel 2
UniProt: Q16515
Pockets: 20 · best druggability 0.79

Structure

x-ray diffraction · 3 distinct chains · 34% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Acid-sensing ion channel 2	protein	434	35% helix, 24% strand	Q16515
B	Acid-sensing ion channel 2	protein	433	33% helix, 24% strand	Q16515
C	Acid-sensing ion channel 2	protein	430	33% helix, 24% strand	Q16515

Pockets

20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1060	0.79	0.81	82	empty
2	249	0.79	0.92	37	empty
3	437	0.78	0.86	43	empty
4	280	0.78	0.90	44	empty
5	766	0.77	0.81	88	empty

Interfaces

3 interfaces between chains.

B–C · 2958 Å² buried · 29 hydrogen bonds · protein-protein
A–B · 2818 Å² buried · 33 hydrogen bonds · protein-protein
A–C · 2798 Å² buried · 33 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 17 disulfide (disulfide).

Compared structures

6L6P · hASIC2a co-crystallized with Mamb-1 · the same entry in another collection · chain A against A, TM-score 1.00
Q16515 · AlphaFold monomer V2.0 prediction for acid-sensing ion channel 2 (Q16515) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q16515
Elsewhere: RCSB PDB 6L6P · PDBe 6L6P · UniProt Q16515

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