Research workbench
Ilvc, a ketol-acid reductoisomerase, from streptococcus PNEUMONIAE_D83G
Analyse Ilvc, a ketol-acid reductoisomerase, from streptococcus PNEUMONIAE_D83G in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6L2S
- Type
- protein
- Length
- 648 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ketol-acid reductoisomerase (NADP(+))
- EC
- 1.1.1.86
- UniProt
- Q04M32
- Pockets
- 7 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 60% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Ketol-acid reductoisomerase (NADP(+)) (EC 1.1.1.86) | protein | 324 | 60% helix, 12% strand | Q04M32 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 606 | 0.77 | 0.83 | 79 | empty |
| 2 | 450 | 0.74 | 0.83 | 51 | empty |
| 3 | 143 | 0.49 | 0.78 | 20 | empty |
| 4 | 155 | 0.48 | 0.77 | 20 | empty |
| 5 | 128 | 0.44 | 0.76 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 5483 Ų buried · 61 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 6L2S · IlvC, a ketol-acid reductoisomerase, from Streptococcus pneumoniae_D83G · the same entry in another collection · chain A against A, TM-score 1.00
- Q04M32 · AlphaFold monomer V2.0 prediction for ketol-acid reductoisomerase (NADP(+)) (Q04M32) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q04M32
- Elsewhere: RCSB PDB 6L2S · PDBe 6L2S · UniProt Q04M32
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