Structure of RLD2 brx domain bound to LZY3 ccl motif

Structure

x-ray diffraction · 2 distinct chains · 23% helix, 38% strand (DSSP).

Ligands and binding sites

• FLC · Citrate anion · additive · 2 copies · chains A, C
• EDO · 1,2-ethanediol · additive · chains A, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

4 interfaces between chains.

• A–B · 770 Ų buried · 14 hydrogen bonds · protein-protein
• C–D · 768 Ų buried · 12 hydrogen bonds · protein-protein
• A–C · 443 Ų buried · 5 hydrogen bonds · protein-protein
• B–C · 35 Ų buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 modified (engineered).

Compared structures

• 6L0W · Structure of RLD2 BRX domain bound to LZY3 CCL motif · the same entry in another collection · chain A against A, TM-score 1.00
• Q5XVG3 · AlphaFold monomer V2.0 prediction for protein lazy 4 (Q5XVG3) · a predicted model of the same protein · chain B against A, TM-score 0.24

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt F4K0X5
• Every structure of UniProt Q5XVG3
• Elsewhere: RCSB PDB 6L0W · PDBe 6L0W · UniProt F4K0X5 · UniProt Q5XVG3