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Crystal structure of the complex of the interaction domains of E. COLI dnab helicase and dnac helicase loader
Analyse Crystal structure of the complex of the interaction domains of E. COLI dnab… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6KZA
- Type
- protein
- Length
- 678 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Replicative DNA helicase; DNA replication protein dnac
- EC
- 3.6.4.12
- UniProt
- A0A4Q4AUR5, A0A4T2UA22
- Pockets
- 9 · best druggability 0.68
Structure
x-ray diffraction · 4 distinct chains · 48% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Replicative DNA helicase (EC 3.6.4.12) | protein | 291 | 44% helix, 18% strand | A0A4Q4AUR5 |
| B | Replicative DNA helicase (EC 3.6.4.12) | protein | 292 | 45% helix, 19% strand | A0A4Q4AUR5 |
| C | DNA replication protein dnac | protein | 47 | 70% helix, 0% strand | A0A4T2UA22 |
| D | DNA replication protein dnac | protein | 48 | 69% helix, 0% strand | A0A4T2UA22 |
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 549 | 0.68 | 0.78 | 44 | empty |
| 2 | 212 | 0.55 | 0.79 | 30 | empty |
| 3 | 221 | 0.51 | 0.76 | 37 | empty |
| 4 | 88 | 0.44 | 0.80 | 23 | empty |
| 5 | 72 | 0.42 | 0.80 | 22 | empty |
Interfaces
3 interfaces between chains.
- B–D · 1508 Ų buried · 17 hydrogen bonds · protein-protein
- A–C · 1371 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 651 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 6KZA · Crystal structure of the complex of the interaction domains of E. coli DnaB helicase and… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A4Q4AUR5
- Every structure of UniProt A0A4T2UA22
- Elsewhere: RCSB PDB 6KZA · PDBe 6KZA · UniProt A0A4Q4AUR5 · UniProt A0A4T2UA22
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