Research workbench
The crystal structure of BAF155 swirm domain and N-terminal elongated HSNF5 RPT1 domain complex: chromatin remodeling complex
Analyse The crystal structure of BAF155 swirm domain and N-terminal elongated HSNF5… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6KZ7
- Type
- protein
- Length
- 353 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SWI/SNF complex subunit SMARCC1; SWI/SNF-related matrix-associated actin-dependent…
- UniProt
- Q92922, Q12824
- Pockets
- 2 · best druggability 0.43
Structure
x-ray diffraction · 3 distinct chains · 50% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SWI/SNF complex subunit SMARCC1 | protein | 94 | 50% helix, 2% strand | Q92922 |
| B, D | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 | protein | 82 | 51% helix, 24% strand | Q12824 |
| C | SWI/SNF complex subunit SMARCC1 | protein | 95 | 49% helix, 1% strand | Q92922 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 133 | 0.43 | 0.76 | 23 | empty |
| 2 | 112 | 0.41 | 0.76 | 22 | empty |
Interfaces
3 interfaces between chains.
- A–B · 873 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 870 Ų buried · 16 hydrogen bonds · protein-protein
- A–C · 403 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 6KZ7 · The crystal structure of BAF155 SWIRM domain and N-terminal elongated hSNF5 RPT1 domain… · the same entry in another collection · chain A against A, TM-score 1.00
- Q92922 · AlphaFold monomer V2.0 prediction for SWI/SNF complex subunit SMARCC1 (Q92922) · a predicted model of the same protein · chain A against A, TM-score 0.96
- Q12824 · AlphaFold monomer V2.0 prediction for SWI/SNF-related matrix- associated actin-dependent… · a predicted model of the same protein · chain B against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92922
- Every structure of UniProt Q12824
- Elsewhere: RCSB PDB 6KZ7 · PDBe 6KZ7 · UniProt Q92922 · UniProt Q12824
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