Research workbench
The structure of the M. tb toxin mazef-MT1 complex
Analyse The structure of the M. tb toxin mazef-MT1 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6KYT
- Type
- protein
- Length
- 1,215 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Endoribonuclease MAZF9; Antitoxin MAZE9
- EC
- 3.1.-.-
- UniProt
- P71650, P0CL61
- Pockets
- 12 · best druggability 0.85
Structure
x-ray diffraction · 11 distinct chains · 35% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Endoribonuclease MAZF9 (EC 3.1.-.-) | protein | 110 | 27% helix, 35% strand | P71650 |
| B | Endoribonuclease MAZF9 (EC 3.1.-.-) | protein | 120 | 28% helix, 33% strand | P71650 |
| P | Antitoxin MAZE9 | protein | 71 | 69% helix, 7% strand | P0CL61 |
| D | Endoribonuclease MAZF9 (EC 3.1.-.-) | protein | 119 | 29% helix, 33% strand | P71650 |
| E | Endoribonuclease MAZF9 (EC 3.1.-.-) | protein | 113 | 31% helix, 35% strand | P71650 |
| F, C | Antitoxin MAZE9 | protein | 73 | 63% helix, 10% strand | P0CL61 |
| G | Endoribonuclease MAZF9 (EC 3.1.-.-) | protein | 118 | 25% helix, 33% strand | P71650 |
| H | Endoribonuclease MAZF9 (EC 3.1.-.-) | protein | 118 | 25% helix, 33% strand | P71650 |
| J | Endoribonuclease MAZF9 (EC 3.1.-.-) | protein | 111 | 27% helix, 35% strand | P71650 |
| K | Endoribonuclease MAZF9 (EC 3.1.-.-) | protein | 117 | 26% helix, 33% strand | P71650 |
| Q | Antitoxin MAZE9 | protein | 72 | 65% helix, 7% strand | P0CL61 |
Pockets
12 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 926 | 0.85 | 0.87 | 99 | empty |
| 2 | 965 | 0.78 | 0.80 | 86 | empty |
| 3 | 415 | 0.67 | 0.79 | 49 | empty |
| 4 | 115 | 0.46 | 0.79 | 22 | empty |
| 5 | 135 | 0.46 | 0.78 | 30 | empty |
Interfaces
28 interfaces between chains.
- F–C · 1518 Ų buried · 16 hydrogen bonds · protein-protein
- P–Q · 1354 Ų buried · 13 hydrogen bonds · protein-protein
- G–C · 1354 Ų buried · 13 hydrogen bonds · protein-protein
- J–Q · 1276 Ų buried · 13 hydrogen bonds · protein-protein
- A–P · 1245 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 6KYT · The structure of the M. tb toxin MazEF-mt1 complex · the same entry in another collection · chain D against D, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P71650
- Every structure of UniProt P0CL61
- Elsewhere: RCSB PDB 6KYT · PDBe 6KYT · UniProt P71650 · UniProt P0CL61
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