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Hslu from staphylococcus aureus

Analyse Hslu from staphylococcus aureus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6KWW
Type: protein
Length: 7,336 residues
Chains: 24
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ATP-dependent protease ATPase subunit hslu
UniProt: P63796
Pockets: 20 · best druggability 0.87

Structure

x-ray diffraction · 24 distinct chains · 54% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
M	ATP-dependent protease ATPase subunit hslu	protein	317	56% helix, 13% strand	P63796
N	ATP-dependent protease ATPase subunit hslu	protein	311	55% helix, 13% strand	P63796
O	ATP-dependent protease ATPase subunit hslu	protein	302	50% helix, 14% strand	P63796
P	ATP-dependent protease ATPase subunit hslu	protein	302	54% helix, 13% strand	P63796
Q	ATP-dependent protease ATPase subunit hslu	protein	303	54% helix, 13% strand	P63796
R	ATP-dependent protease ATPase subunit hslu	protein	330	57% helix, 13% strand	P63796
S	ATP-dependent protease ATPase subunit hslu	protein	309	55% helix, 12% strand	P63796
T	ATP-dependent protease ATPase subunit hslu	protein	330	53% helix, 12% strand	P63796
U	ATP-dependent protease ATPase subunit hslu	protein	332	54% helix, 12% strand	P63796
V	ATP-dependent protease ATPase subunit hslu	protein	301	55% helix, 13% strand	P63796
W	ATP-dependent protease ATPase subunit hslu	protein	323	60% helix, 13% strand	P63796
X	ATP-dependent protease ATPase subunit hslu	protein	316	56% helix, 13% strand	P63796
A	ATP-dependent protease ATPase subunit hslu	protein	307	53% helix, 14% strand	P63796
B	ATP-dependent protease ATPase subunit hslu	protein	292	51% helix, 14% strand	P63796
C	ATP-dependent protease ATPase subunit hslu	protein	296	56% helix, 14% strand	P63796
D	ATP-dependent protease ATPase subunit hslu	protein	296	50% helix, 14% strand	P63796
E	ATP-dependent protease ATPase subunit hslu	protein	292	51% helix, 13% strand	P63796
F	ATP-dependent protease ATPase subunit hslu	protein	298	56% helix, 14% strand	P63796
G	ATP-dependent protease ATPase subunit hslu	protein	287	49% helix, 14% strand	P63796
H	ATP-dependent protease ATPase subunit hslu	protein	304	54% helix, 13% strand	P63796
I	ATP-dependent protease ATPase subunit hslu	protein	291	52% helix, 14% strand	P63796
J	ATP-dependent protease ATPase subunit hslu	protein	305	53% helix, 12% strand	P63796
K	ATP-dependent protease ATPase subunit hslu	protein	297	53% helix, 13% strand	P63796
L	ATP-dependent protease ATPase subunit hslu	protein	295	51% helix, 12% strand	P63796

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	991	0.87	0.88	112	empty
2	923	0.86	0.88	100	empty
3	820	0.86	0.88	97	empty
4	898	0.86	0.87	92	empty
5	845	0.85	0.88	88	empty

Interfaces

67 interfaces between chains.

T–U · 2283 Å² buried · 21 hydrogen bonds · protein-protein
N–O · 2243 Å² buried · 18 hydrogen bonds · protein-protein
D–E · 2176 Å² buried · 22 hydrogen bonds · protein-protein
O–P · 2175 Å² buried · 18 hydrogen bonds · protein-protein
V–W · 2138 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

6KWW · HslU from Staphylococcus aureus · the same entry in another collection · chain W against W, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P63796
Elsewhere: RCSB PDB 6KWW · PDBe 6KWW · UniProt P63796

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