Research workbench
Fatty acid amide hydrolase
Analyse Fatty acid amide hydrolase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6KVR
- Type
- protein
- Length
- 1,140 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fatty acid amide hydrolase
- UniProt
- G1UA68
- Pockets
- 9 · best druggability 0.85
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fatty acid amide hydrolase | protein | 571 | 44% helix, 13% strand | G1UA68 |
| B | Fatty acid amide hydrolase | protein | 569 | 44% helix, 13% strand | G1UA68 |
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1145 | 0.85 | 0.87 | 128 | empty |
| 2 | 200 | 0.53 | 0.78 | 23 | empty |
| 3 | 189 | 0.51 | 0.77 | 24 | empty |
| 4 | 117 | 0.37 | 0.74 | 18 | empty |
| 5 | 66 | 0.37 | 0.78 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1804 Ų buried · 25 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 18 modified (engineered).
Compared structures
- 6KVR · Fatty acid amide hydrolase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G1UA68
- Elsewhere: RCSB PDB 6KVR · PDBe 6KVR · UniProt G1UA68
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