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Crystal structure of legionella pneumophila deubiquitinase CEG23

Analyse Crystal structure of legionella pneumophila deubiquitinase CEG23 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6KS5
Type: protein
Length: 614 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Type IV secretion protein dot
UniProt: A0A2S6F7D4
Pockets: 10 · best druggability 0.60

Structure

x-ray diffraction · 2 distinct chains · 46% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Type IV secretion protein dot	protein	301	47% helix, 5% strand	A0A2S6F7D4
B	Type IV secretion protein dot	protein	313	45% helix, 6% strand	A0A2S6F7D4

Pockets

10 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	434	0.60	0.75	50	empty
2	125	0.49	0.79	17	empty
3	138	0.46	0.77	38	empty
4	175	0.46	0.75	37	empty
5	118	0.42	0.76	22	empty

Interfaces

1 interface between chains.

A–B · 744 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

6KS5 · Crystal structure of Legionella pneumophila deubiquitinase Ceg23 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A2S6F7D4
Elsewhere: RCSB PDB 6KS5 · PDBe 6KS5 · UniProt A0A2S6F7D4

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