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Structure of anti-ghrelin receptor antibody

Analyse Structure of anti-ghrelin receptor antibody in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6KS2
Type: protein
Length: 872 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: FAB7881 light chain (fabl); FAB7881 heavy chain (fabh)
Pockets: 10 · best druggability 0.65

Structure

x-ray diffraction · 3 distinct chains · 8% helix, 54% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	FAB7881 light chain (fabl)	protein	219	7% helix, 53% strand	—
B	FAB7881 heavy chain (fabh)	protein	216	7% helix, 55% strand	—
D	FAB7881 heavy chain (fabh)	protein	218	8% helix, 54% strand	—

Pockets

10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	722	0.65	0.74	57	empty
2	408	0.63	0.78	57	empty
3	598	0.61	0.74	64	empty
4	110	0.57	0.85	20	empty
5	99	0.52	0.83	21	empty

Interfaces

4 interfaces between chains.

C–D · 1863 Å² buried · 18 hydrogen bonds · protein-protein
A–B · 1756 Å² buried · 23 hydrogen bonds · protein-protein
B–C · 544 Å² buried · 7 hydrogen bonds · protein-protein
A–C · 109 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 9 disulfide (disulfide).

Compared structures

6KS2 · Structure of anti-Ghrelin receptor antibody · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6KS2 · PDBe 6KS2

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