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Structure of sendai virus Y3/ALIX-BRO1 domain complex

Analyse Structure of sendai virus Y3/ALIX-BRO1 domain complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
6KP3
Type
protein
Length
469 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Programmed cell death 6-interacting protein; C' protein
UniProt
Q8WUM4, Q5ECE0
Pockets
5 · best druggability 0.64

Structure

x-ray diffraction · 2 distinct chains · 65% helix, 2% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AProgrammed cell death 6-interacting proteinprotein35761% helix, 3% strandQ8WUM4
BC' proteinprotein11279% helix, 0% strandQ5ECE0

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
15180.640.7643empty
22290.500.7523empty
3530.360.7917empty
4580.340.7817empty
5530.280.7513empty

Interfaces

1 interface between chains.

  • A–B · 629 Ų buried · 6 hydrogen bonds · protein-protein

Compared structures

  • 6KP3 · Structure of sendai virus Y3/ALIX-BRO1 domain complex · the same entry in another collection · chain A against A, TM-score 1.00
  • Q8WUM4 · AlphaFold monomer V2.0 prediction for programmed cell death 6-interacting protein (Q8WUM4) · a predicted model of the same protein · chain A against A, TM-score 0.98

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