Research workbench
Structure of apo machupo virus polymerase
Analyse Structure of apo machupo virus polymerase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6KLD
- Type
- protein
- Length
- 1,617 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-directed RNA polymerase L
- EC
- 2.7.7.48, 3.1.-.-
- UniProt
- Q6IVU0
- Ligands
- MN, ZN
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 1 distinct chain · 46% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA-directed RNA polymerase L (EC 2.7.7.48, 3.1.-.-) | protein | 1617 | 46% helix, 8% strand | Q6IVU0 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1050 | 0.80 | 0.82 | 91 | empty |
| 2 | 920 | 0.78 | 0.81 | 109 | empty |
| 3 | 642 | 0.76 | 0.82 | 84 | empty |
| 4 | 767 | 0.75 | 0.80 | 89 | empty |
| 5 | 660 | 0.71 | 0.78 | 71 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 6KLD · Structure of apo Machupo virus polymerase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6IVU0
- Elsewhere: RCSB PDB 6KLD · PDBe 6KLD · UniProt Q6IVU0
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