Research workbench
Crystal structure of the SMARCB1/SMARCC2 subcomplex
Analyse Crystal structure of the SMARCB1/SMARCC2 subcomplex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6KAG
- Type
- protein
- Length
- 350 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B…
- UniProt
- Q12824, Q8TAQ2
- Pockets
- 3 · best druggability 0.38
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 | protein | 164 | 35% helix, 25% strand | Q12824 |
| B, C | SWI/SNF complex subunit SMARCC2 | protein | 93 | 52% helix, 1% strand | Q8TAQ2 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 66 | 0.38 | 0.78 | 10 | empty |
| 2 | 81 | 0.35 | 0.75 | 13 | empty |
| 3 | 64 | 0.31 | 0.75 | 14 | empty |
Interfaces
2 interfaces between chains.
- A–C · 1196 Ų buried · 26 hydrogen bonds · protein-protein
- A–B · 693 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 6KAG · Crystal structure of the SMARCB1/SMARCC2 subcomplex · the same entry in another collection · chain A against A, TM-score 1.00
- Q8TAQ2 · AlphaFold monomer V2.0 prediction for SWI/SNF complex subunit SMARCC2 (Q8TAQ2) · a predicted model of the same protein · chain B against A, TM-score 0.98
- Q12824 · AlphaFold monomer V2.0 prediction for SWI/SNF-related matrix- associated actin-dependent… · a predicted model of the same protein · chain A against A, TM-score 0.62
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12824
- Every structure of UniProt Q8TAQ2
- Elsewhere: RCSB PDB 6KAG · PDBe 6KAG · UniProt Q12824 · UniProt Q8TAQ2
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