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The apo structure of nrs-1 C terminal region (305-718)

Analyse The apo structure of nrs-1 C terminal region (305-718) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6K9C
Type: protein
Length: 830 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Primase
UniProt: M5AAG8
Ligands: HG, SO4
Pockets: 9 · best druggability 0.82

Structure

x-ray diffraction · 2 distinct chains · 41% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Primase	protein	416	41% helix, 20% strand	M5AAG8
B	Primase	protein	414	41% helix, 20% strand	M5AAG8

Ligands and binding sites

HG · Mercury (II) ion · metal · 2 copies · chains A, B
SO4 · Sulfate ion · ion · 5 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1133	0.82	0.83	90	SO4
2	935	0.78	0.81	84	SO4
3	204	0.49	0.76	31	empty
4	157	0.46	0.76	25	empty
5	120	0.45	0.77	16	empty

Interfaces

1 interface between chains.

A–B · 2270 Å² buried · 26 hydrogen bonds · protein-protein

Compared structures

6K9C · The apo structure of NrS-1 C terminal region (305-718) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt M5AAG8
Elsewhere: RCSB PDB 6K9C · PDBe 6K9C · UniProt M5AAG8

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