Research workbench
Crystal structure of the class a beta-lactamase L2 from stenotrophomonas maltophilia
Analyse Crystal structure of the class a beta-lactamase L2 from stenotrophomonas… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1N4O
- Type
- protein
- Length
- 539 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- L2 beta-lactamase
- EC
- 3.5.2.6
- UniProt
- Q9RBQ1
- Ligands
- SO4
- Pockets
- 9 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | L2 beta-lactamase (EC 3.5.2.6) | protein | 267 | 48% helix, 19% strand | Q9RBQ1 |
| B | L2 beta-lactamase (EC 3.5.2.6) | protein | 272 | 45% helix, 19% strand | Q9RBQ1 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 71 | 0.58 | 0.89 | 22 | empty |
| 2 | 89 | 0.45 | 0.80 | 16 | empty |
| 3 | 100 | 0.43 | 0.78 | 17 | empty |
| 4 | 113 | 0.41 | 0.77 | 14 | empty |
| 5 | 83 | 0.39 | 0.78 | 22 | SO4 |
Interfaces
1 interface between chains.
- A–B · 1006 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 1N4O · Crystal structure of the Class A beta-lactamase L2 from Stenotrophomonas maltophilia · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9RBQ1
- Elsewhere: RCSB PDB 1N4O · PDBe 1N4O · UniProt Q9RBQ1
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