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Global regulatory element sarx

Analyse Global regulatory element sarx in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6K8E
Type: protein
Length: 226 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hth-type transcriptional regulator sarx
UniProt: Q2G0D1
Pockets: 3 · best druggability 0.72

Structure

x-ray diffraction · 2 distinct chains · 67% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hth-type transcriptional regulator sarx	protein	112	67% helix, 9% strand	Q2G0D1
D	Hth-type transcriptional regulator sarx	protein	114	68% helix, 9% strand	Q2G0D1

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	243	0.72	0.86	21	empty
2	186	0.63	0.83	21	empty
3	201	0.47	0.74	21	empty

Interfaces

1 interface between chains.

A–D · 931 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

6K8E · Global regulatory element SarX · the same entry in another collection · chain A against A, TM-score 1.00
Q2G0D1 · AlphaFold monomer V2.0 prediction for hth-type transcriptional regulator sarx (Q2G0D1) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q2G0D1
Elsewhere: RCSB PDB 6K8E · PDBe 6K8E · UniProt Q2G0D1

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