Research workbench
Complex structure of LILRB4 and H128-3 antibody
Analyse Complex structure of LILRB4 and H128-3 antibody in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6K7O
- Type
- protein
- Length
- 2,148 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leukocyte immunoglobulin-like receptor subfamily B member 4; H128-3 Fab heavy chain…
- UniProt
- Q8NHJ6
- Pockets
- 20 · best druggability 0.76
Structure
x-ray diffraction · 3 distinct chains · 6% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, P, R, Q | Leukocyte immunoglobulin-like receptor subfamily B member 4 | protein | 94 | 3% helix, 45% strand | Q8NHJ6 |
| B, D, F, H | H128-3 Fab heavy chain | protein | 225 | 7% helix, 51% strand | — |
| C, E, G, L | H128-3 Fab light chain | protein | 218 | 7% helix, 50% strand | — |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1080 | 0.76 | 0.78 | 91 | empty |
| 2 | 454 | 0.68 | 0.80 | 57 | empty |
| 3 | 493 | 0.65 | 0.77 | 54 | empty |
| 4 | 459 | 0.63 | 0.77 | 55 | empty |
| 5 | 402 | 0.60 | 0.76 | 49 | empty |
Interfaces
24 interfaces between chains.
- F–G · 2256 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 2215 Ų buried · 18 hydrogen bonds · protein-protein
- D–E · 2191 Ų buried · 21 hydrogen bonds · protein-protein
- H–L · 2165 Ų buried · 16 hydrogen bonds · protein-protein
- C–L · 915 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 24 disulfide (disulfide).
Compared structures
- 6K7O · Complex structure of LILRB4 and h128-3 antibody · the same entry in another collection · chain Q against Q, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8NHJ6
- Elsewhere: RCSB PDB 6K7O · PDBe 6K7O · UniProt Q8NHJ6
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