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Application of anti-helix antibodies in protein structure determination (8188-3LRH)

Analyse Application of anti-helix antibodies in protein structure determination… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6K64
Type: protein
Length: 330 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 3LRH intrabody; Protein a
Pockets: 4 · best druggability 0.67

Structure

x-ray diffraction · 2 distinct chains · 30% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	3LRH intrabody	protein	109	3% helix, 51% strand	—
H, C	Protein a	protein	56	84% helix, 0% strand	—

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	440	0.67	0.79	35	empty
2	191	0.48	0.76	24	empty
3	199	0.47	0.75	28	empty
4	51	0.32	0.77	11	empty

Interfaces

4 interfaces between chains.

B–H · 660 Å² buried · 1 hydrogen bond · protein-protein
A–C · 660 Å² buried · 1 hydrogen bond · protein-protein
A–B · 362 Å² buried · 7 hydrogen bonds · protein-protein
B–C · 258 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

6K64 · Application of anti-helix antibodies in protein structure determination (8188-3LRH) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6K64 · PDBe 6K64

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