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Structure of glargine insulin in 20% acetic acid-D4 (pH 1.9)

Analyse Structure of glargine insulin in 20% acetic acid-D4 (pH 1.9) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
6K59
Type
protein
Length
53 residues
Chains
2
Method
solution nmr
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Glargine insulin chain-a; Glargine insulin chain-B

Structure

solution nmr · 2 distinct chains · 42% helix, 0% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AGlargine insulin chain-aprotein2157% helix, 0% strand—
BGlargine insulin chain-Bprotein3231% helix, 0% strand—

Interfaces

1 interface between chains.

  • A–B · 819 Ų buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

  • 6K59 · Structure of Glargine insulin in 20% acetic acid-d4 (pH 1.9) · the same entry in another collection · chain A against A, TM-score 1.00

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