Research workbench
Crystal structure of HLA-C08 in complex with a tumor MUT9M peptide
Analyse Crystal structure of HLA-C08 in complex with a tumor MUT9M peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6JTP
- Type
- protein
- Length
- 380 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HLA class I antigen, CW8.2 alpha chain; Beta-2-microglobulin; 9-mer peptide
- UniProt
- C1K0Y1, P61769
- Pockets
- 3 · best druggability 0.67
Structure
x-ray diffraction · 3 distinct chains · 20% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HLA class I antigen, CW8.2 alpha chain | protein | 273 | 27% helix, 40% strand | C1K0Y1 |
| B | Beta-2-microglobulin | protein | 98 | 0% helix, 50% strand | P61769 |
| C | 9-mer peptide | protein | 9 | 0% helix, 0% strand | — |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 563 | 0.67 | 0.77 | 55 | empty |
| 2 | 154 | 0.50 | 0.78 | 29 | empty |
| 3 | 174 | 0.47 | 0.76 | 25 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1184 Ų buried · 18 hydrogen bonds · protein-protein
- A–C · 715 Ų buried · 23 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C1K0Y1
- Every structure of UniProt P61769
- Elsewhere: RCSB PDB 6JTP · PDBe 6JTP · UniProt C1K0Y1 · UniProt P61769
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