Research workbench
Crystal structure of HLA-C05 in complex with a tumor MUT10M peptide
Analyse Crystal structure of HLA-C05 in complex with a tumor MUT10M peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6JTO
- Type
- protein
- Length
- 381 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HLA class I histocompatibility antigen, cw-5 alpha chain; Beta-2-microglobulin; 10-mer…
- UniProt
- Q9TNN7, P61769
- Pockets
- 4 · best druggability 0.68
Structure
x-ray diffraction · 3 distinct chains · 21% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HLA class I histocompatibility antigen, cw-5 alpha chain | protein | 273 | 29% helix, 40% strand | Q9TNN7 |
| B | Beta-2-microglobulin | protein | 98 | 0% helix, 50% strand | P61769 |
| C | 10-mer peptide | protein | 10 | 0% helix, 0% strand | — |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 555 | 0.68 | 0.78 | 50 | empty |
| 2 | 164 | 0.50 | 0.78 | 33 | empty |
| 3 | 130 | 0.42 | 0.76 | 25 | empty |
| 4 | 57 | 0.35 | 0.78 | 15 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1324 Ų buried · 17 hydrogen bonds · protein-protein
- A–C · 787 Ų buried · 20 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9TNN7
- Every structure of UniProt P61769
- Elsewhere: RCSB PDB 6JTO · PDBe 6JTO · UniProt Q9TNN7 · UniProt P61769
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