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The ligand-free structure of human ppargamma lbd in the presence of the src-1 coactivator peptide

Analyse The ligand-free structure of human ppargamma lbd in the presence of the src-1… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6JQ7
Type: protein
Length: 271 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Peroxisome proliferator-activated receptor gamma; 16-mer peptide from nuclear receptor…
EC: 2.3.1.48
UniProt: P37231, Q15788
Pockets: 1 · best druggability 0.80

Structure

x-ray diffraction · 2 distinct chains · 68% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Peroxisome proliferator-activated receptor gamma	protein	260	67% helix, 5% strand	P37231
B	16-mer peptide from nuclear receptor coactivator 1 (EC 2.3.1.48)	protein	11	73% helix, 0% strand	Q15788

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	420	0.80	0.88	49	empty

Interfaces

1 interface between chains.

A–B · 668 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

6JQ7 · The ligand-free structure of human PPARgamma LBD in the presence of the SRC-1 coactivator… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37231
Every structure of UniProt Q15788
Elsewhere: RCSB PDB 6JQ7 · PDBe 6JQ7 · UniProt P37231 · UniProt Q15788

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