Research workbench
Crystal structures of branched-chain aminotransferase from pseudomonas sp. UW4
Analyse Crystal structures of branched-chain aminotransferase from pseudomonas sp. UW4 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6JIF
- Type
- protein
- Length
- 667 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Branched-chain-amino-acid aminotransferase
- EC
- 2.6.1.42
- UniProt
- K9NJ94
- Ligands
- PLP
- Pockets
- 4 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 27% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Branched-chain-amino-acid aminotransferase (EC 2.6.1.42) | protein | 333 | 27% helix, 34% strand | K9NJ94 |
| B | Branched-chain-amino-acid aminotransferase (EC 2.6.1.42) | protein | 334 | 26% helix, 32% strand | K9NJ94 |
Ligands and binding sites
- PLP · Pyridoxal-5'-phosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 292 | 0.81 | 0.92 | 44 | PLP |
| 2 | 347 | 0.78 | 0.88 | 52 | PLP |
| 3 | 178 | 0.57 | 0.81 | 37 | empty |
| 4 | 94 | 0.46 | 0.80 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 2531 Ų buried · 46 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 cofactor (pyridoxal phosphate Schiff base).
Compared structures
- 6JIF · Crystal Structures of Branched-Chain Aminotransferase from Pseudomonas sp. UW4 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt K9NJ94
- Elsewhere: RCSB PDB 6JIF · PDBe 6JIF · UniProt K9NJ94
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