Research workbench
Crystal structure of CISG15/NS1B complex
Analyse Crystal structure of CISG15/NS1B complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6JH0
- Type
- protein
- Length
- 494 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Non-structural protein 1; ISG15 ubiquitin-like modifier
- UniProt
- P03502, E2R7R1
- Pockets
- 3 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C, A | Non-structural protein 1 | protein | 94 | 77% helix, 0% strand | P03502 |
| D, B | ISG15 ubiquitin-like modifier | protein | 153 | 24% helix, 34% strand | E2R7R1 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 206 | 0.60 | 0.81 | 20 | empty |
| 2 | 140 | 0.44 | 0.76 | 26 | empty |
| 3 | 52 | 0.26 | 0.74 | 13 | empty |
Interfaces
5 interfaces between chains.
- C–A · 1849 Ų buried · 26 hydrogen bonds · protein-protein
- C–B · 644 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 590 Ų buried · 2 hydrogen bonds · protein-protein
- C–D · 408 Ų buried · 3 hydrogen bonds · protein-protein
- A–B · 348 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 6JH0 · Crystal structure of cISG15/NS1B complex · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03502
- Every structure of UniProt E2R7R1
- Elsewhere: RCSB PDB 6JH0 · PDBe 6JH0 · UniProt P03502 · UniProt E2R7R1
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