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Crystal structure of PA0833 periplasmic domain from pseudomonas aeruginosa reveals an unexpected enlarged peptidoglycan binding pocket

Analyse Crystal structure of PA0833 periplasmic domain from pseudomonas aeruginosa… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6JFW
Type: protein
Length: 564 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: PA0833-pd protein
UniProt: Q9I5A7
Pockets: 6 · best druggability 0.54

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	PA0833-pd protein	protein	141	43% helix, 25% strand	Q9I5A7

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	269	0.54	0.76	27	empty
2	220	0.51	0.76	19	empty
3	205	0.51	0.77	29	empty
4	164	0.44	0.75	24	empty
5	95	0.39	0.77	23	empty

Interfaces

3 interfaces between chains.

C–D · 484 Å² buried · 2 hydrogen bonds · protein-protein
A–B · 454 Å² buried · 2 hydrogen bonds · protein-protein
B–C · 159 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

6JFW · Crystal structure of PA0833 periplasmic domain from Pseudomonas aeruginosa reveals an… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9I5A7
Elsewhere: RCSB PDB 6JFW · PDBe 6JFW · UniProt Q9I5A7

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