Research workbench
Crystal structures of class mu chimeric GST isoenzymes M1-2 and M2-1
Analyse Crystal structures of class mu chimeric GST isoenzymes M1-2 and M2-1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1B4P
- Type
- protein
- Length
- 217 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (glutathione S-transferase)
- EC
- 2.5.1.18
- UniProt
- P08010
- Ligands
- GPS, SO4
- Pockets
- 1 · best druggability 0.47
Structure
x-ray diffraction · 1 distinct chain · 51% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (glutathione S-transferase) (EC 2.5.1.18) | protein | 217 | 51% helix, 10% strand | P08010 |
Ligands and binding sites
- GPS · L-gamma-glutamyl-S-[(9S,10S)-10-hydroxy-9,10-dihydrophenanthren-9-yl]-L-cysteinylglycine · ligand · 2 copies · chains A
- SO4 · Sulfate ion · ion · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 138 | 0.47 | 0.78 | 25 | GPS |
Compared structures
- 1B4P · Crystal structures of class mu chimeric GST isoenzymes M1-2 and M2-1 · the same entry in another collection · chain A against A, TM-score 1.00
- P08010 · AlphaFold monomer V2.0 prediction for glutathione S-transferase mu 2 (P08010) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08010
- Elsewhere: RCSB PDB 1B4P · PDBe 1B4P · UniProt P08010
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