Research workbench
Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neamine analog (axial 4'-F)
Analyse Crystal structure of the bacterial ribosomal decoding site in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6JBF
- Type
- RNA
- Length
- 92 nucleotides
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA (5'- R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP* C)-3')
- Ligands
- V71
- Pockets
- 2 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | RNA (5'- R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP* C)-3') | rna | 23 | — | — |
Ligands and binding sites
- V71 · (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2, 6-diamino-2,4,6-trideoxy-4-fluoro-alpha-D-galactopyranoside · ligand · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1021 | 0.74 | 0.78 | 50 | empty |
| 2 | 998 | 0.73 | 0.77 | 49 | V71 |
Interfaces
4 interfaces between chains.
- A–B · 1144 Ų buried · 113 hydrogen bonds · nucleic-nucleic
- C–D · 1041 Ų buried · 106 hydrogen bonds · nucleic-nucleic
- A–C · 203 Ų buried · 3 hydrogen bonds · nucleic-nucleic
- B–D · 115 Ų buried · 0 hydrogen bonds · nucleic-nucleic
Compared structures
- 6JBF · Crystal structure of the bacterial ribosomal decoding site in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6JBF · PDBe 6JBF
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