Research workbench

Otsa apo structure

Analyse Otsa apo structure in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6JAK
Type: protein
Length: 1,791 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Trehalose-6-phosphate synthase
EC: 2.4.1.15
UniProt: A0A376VH75
Pockets: 18 · best druggability 0.78

Structure

x-ray diffraction · 2 distinct chains · 47% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Trehalose-6-phosphate synthase (EC 2.4.1.15)	protein	450	48% helix, 20% strand	A0A376VH75
B, C, D	Trehalose-6-phosphate synthase (EC 2.4.1.15)	protein	447	47% helix, 19% strand	A0A376VH75

Pockets

18 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1059	0.78	0.80	93	empty
2	916	0.73	0.77	62	empty
3	829	0.72	0.77	56	empty
4	937	0.71	0.76	60	empty
5	147	0.71	0.90	20	empty

Interfaces

4 interfaces between chains.

A–D · 1120 Å² buried · 11 hydrogen bonds · protein-protein
B–C · 1111 Å² buried · 8 hydrogen bonds · protein-protein
A–B · 1085 Å² buried · 16 hydrogen bonds · protein-protein
C–D · 1077 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

6JAK · OtsA apo structure · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A376VH75
Elsewhere: RCSB PDB 6JAK · PDBe 6JAK · UniProt A0A376VH75

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.