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Crystal structure of toxin tglt (unusual type guanylyltransferase-like toxin, RV1045) mutant S78A co-expressed with taka from mycobacterium tuberculosis

Analyse Crystal structure of toxin tglt (unusual type guanylyltransferase-like toxin… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6J7R
Type: protein
Length: 289 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Guanylyltransferase-like toxin
UniProt: P96356
Ligands: MG
Pockets: 3 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Guanylyltransferase-like toxin	protein	289	43% helix, 16% strand	P96356

Ligands and binding sites

MG · Magnesium ion · metal · 20 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	457	0.69	0.80	41	MG
2	71	0.49	0.84	19	empty
3	59	0.32	0.76	16	empty

Compared structures

6J7R · Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045)… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P96356
Elsewhere: RCSB PDB 6J7R · PDBe 6J7R · UniProt P96356

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