Research workbench
Crystal structure of tyrosinase caddy PROTEIN(MELC1)WITH tyrosinase (MELC2)FROM streptomyces avermitilis in complex with zinc ion
Analyse Crystal structure of tyrosinase caddy PROTEIN(MELC1)WITH tyrosinase (MELC2)FROM… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6J2U
- Type
- protein
- Length
- 345 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosinase co-factor protein; Tyrosinase
- UniProt
- Q93HL1, Q93HL2
- Ligands
- ZN
- Pockets
- 1 · best druggability 0.46
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosinase co-factor protein | protein | 72 | 17% helix, 46% strand | Q93HL1 |
| B | Tyrosinase | protein | 273 | 42% helix, 4% strand | Q93HL2 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 106 | 0.46 | 0.80 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1018 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 6J2U · Crystal structure of Tyrosinase caddy protein(MelC1)with Tyrosinase (MelC2)from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q93HL1
- Every structure of UniProt Q93HL2
- Elsewhere: RCSB PDB 6J2U · PDBe 6J2U · UniProt Q93HL1 · UniProt Q93HL2
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