Research workbench
Engineered lipocalin flua in complex with fluorescein
Analyse Engineered lipocalin flua in complex with fluorescein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1N0S
- Type
- protein
- Length
- 346 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bilin-binding protein
- UniProt
- P09464
- Ligands
- FLU, SO4
- Pockets
- 5 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 15% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Bilin-binding protein | protein | 173 | 15% helix, 48% strand | P09464 |
Ligands and binding sites
- FLU · 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-benzoic acid · ligand · 2 copies · chains A, B
- SO4 · Sulfate ion · ion · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 507 | 0.77 | 0.85 | 42 | FLU |
| 2 | 589 | 0.77 | 0.83 | 55 | FLU, SO4 |
| 3 | 63 | 0.36 | 0.77 | 15 | empty |
| 4 | 58 | 0.31 | 0.75 | 14 | empty |
| 5 | 53 | 0.31 | 0.76 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 769 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09464
- Elsewhere: RCSB PDB 1N0S · PDBe 1N0S · UniProt P09464
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.