Research workbench
Crystal structure analysis of tric counter-ion channels in calcium release
Analyse Crystal structure analysis of tric counter-ion channels in calcium release in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6IZ4
- Type
- protein
- Length
- 2,688 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Trimeric intracellular cation channel type B-B
- UniProt
- Q6GN30
- Pockets
- 20 · best druggability 0.87
Structure
x-ray diffraction · 1 distinct chain · 78% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L | Trimeric intracellular cation channel type B-B | protein | 224 | 78% helix, 0% strand | Q6GN30 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 912 | 0.87 | 0.88 | 74 | empty |
| 2 | 904 | 0.86 | 0.87 | 77 | empty |
| 3 | 989 | 0.82 | 0.84 | 81 | empty |
| 4 | 950 | 0.82 | 0.83 | 80 | empty |
| 5 | 954 | 0.82 | 0.83 | 81 | empty |
Interfaces
23 interfaces between chains.
- J–L · 822 Ų buried · 5 hydrogen bonds · protein-protein
- D–E · 813 Ų buried · 4 hydrogen bonds · protein-protein
- H–I · 812 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 811 Ų buried · 6 hydrogen bonds · protein-protein
- E–F · 808 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 6IZ4 · Crystal Structure Analysis of TRIC counter-ion channels in calcium release · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6GN30
- Elsewhere: RCSB PDB 6IZ4 · PDBe 6IZ4 · UniProt Q6GN30
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