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Crystal structure of the acyltransferase domain from the second module of the salinomycin polyketide synthase

Analyse Crystal structure of the acyltransferase domain from the second module of the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6IYO
Type: protein
Length: 836 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Type I modular polyketide synthase
UniProt: H1ZZT3
Pockets: 6 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 50% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Type I modular polyketide synthase	protein	421	50% helix, 17% strand	H1ZZT3
B	Type I modular polyketide synthase	protein	415	49% helix, 17% strand	H1ZZT3

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1071	0.81	0.82	90	empty
2	365	0.68	0.81	41	empty
3	252	0.67	0.84	33	empty
4	62	0.40	0.80	13	empty
5	79	0.39	0.78	21	empty

Interfaces

1 interface between chains.

A–B · 3841 Å² buried · 55 hydrogen bonds · protein-protein

Compared structures

6IYO · Crystal Structure of the acyltransferase domain from the second module of the salinomycin… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt H1ZZT3
Elsewhere: RCSB PDB 6IYO · PDBe 6IYO · UniProt H1ZZT3

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