Research workbench
The ptp domain of human PTPN14 in a complex with the CR3 domain of HPV18 E7
Analyse The ptp domain of human PTPN14 in a complex with the CR3 domain of HPV18 E7 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6IWD
- Type
- protein
- Length
- 338 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein phosphatase non-receptor type 14; HPV18 E7
- EC
- 3.1.3.48
- UniProt
- Q15678, Q76Z96
- Ligands
- ZN, PO4, CL
- Pockets
- 5 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) | protein | 289 | 38% helix, 23% strand | Q15678 |
| B | HPV18 E7 | protein | 49 | 33% helix, 33% strand | Q76Z96 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains B
- PO4 · Phosphate ion · ion · 2 copies · chains A, B
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 125 | 0.50 | 0.80 | 20 | empty |
| 2 | 142 | 0.48 | 0.78 | 24 | empty |
| 3 | 64 | 0.41 | 0.80 | 19 | empty |
| 4 | 79 | 0.37 | 0.77 | 19 | empty |
| 5 | 98 | 0.36 | 0.75 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 822 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 6IWD · The PTP domain of human PTPN14 in a complex with the CR3 domain of HPV18 E7 · the same entry in another collection · chain A against A, TM-score 1.00
- Q15678 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 14… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15678
- Every structure of UniProt Q76Z96
- Elsewhere: RCSB PDB 6IWD · PDBe 6IWD · UniProt Q15678 · UniProt Q76Z96
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