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C-terminal emap II-like domain of P43 refined against twinned data

Analyse C-terminal emap II-like domain of P43 refined against twinned data in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6IPA
Type: protein
Length: 660 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Aminoacyl-tRNA synthetase-interacting multifunctional protein P43
UniProt: A0A1G4HHT8
Pockets: 8 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 10% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Aminoacyl-tRNA synthetase-interacting multifunctional protein P43	protein	165	10% helix, 39% strand	A0A1G4HHT8

Pockets

8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	630	0.68	0.77	50	empty
2	680	0.67	0.75	57	empty
3	220	0.51	0.76	28	empty
4	202	0.49	0.75	27	empty
5	245	0.48	0.74	37	empty

Interfaces

3 interfaces between chains.

A–B · 514 Å² buried · 1 hydrogen bond · protein-protein
A–C · 447 Å² buried · 3 hydrogen bonds · protein-protein
C–D · 429 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

6IPA · C-terminal EMAP II-like domain of p43 refined against twinned data · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A1G4HHT8
Elsewhere: RCSB PDB 6IPA · PDBe 6IPA · UniProt A0A1G4HHT8

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